Sevoflurane Preconditioning Induces Neuroprotection Through Reactive Oxygen Species-Mediated Up-Regulation of Antioxidant Enzymes in Rats

Abstract

Sevoflurane preconditioning induces cerebral ischemic tolerance in a dose- response manner through ROS release and consequent up-regulation of antioxidant enzyme activity before ischemic injury in rats. Serum GSH-px activity could be developed as a marker to assess the effectiveness of sevoflurane preconditioning before ischemia.