Science · 1973 · 126 citations · 14 references
Muscle FunctionCell CultureCellular PhysiologyNeuromuscular BlockadeMuscle PhysiologyKinesiologySkeletal MuscleCell PhysiologyHealth SciencesMechanobiologyMuscle Acetylcholine SensitivityMolecular PhysiologyMembrane BiologyNervous SystemNeuromuscular PhysiologyCell BiologyMuscle FibersInactive FibersMuscle ActivityPhysiologyElectrophysiologyTissue CultureMedicine
Muscle in tissue culture provides a good system for studying longterm changes in surface membrane acetylcholine sensitivity. Muscle fibers stimulated intermittently over prolonged periods are less sensitive to iontophoretically applied acetylcholine and bind less (125)I-labeled alpha-bungarotoxin than inactive fibers.
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