Significantly Enhanced DNA Thermal Stability Resulting from Porphyrin H‐Aggregate Formation in the Minor Groove of the Duplex

Abstract

Too groovy: The covalent attachment of up to four porphyrins to complementary strands led to the formation of DNA porphyrin zippers with significantly increased DNA duplex stability. This is a result of H-aggregate formation in the minor groove. To the best of our knowledge this is the first report showing such a significant thermal duplex stabilization.