Atypical Scleroderma Associated with Multiple Myeloma

Abstract

A case of atypical scleroderma associated with multiple myeloma is reported. The patient was a 50-year-old male; morphea-like plaques with brownish pigmentation were scattered on the whole body and sclerodactylia-like changes, contracture of fingers and polymyositis were observed. Histological findings in the sclerotic lesions were consistent with scleroderma. One year later, M-protein (IgG, kappa-chain) appeared in the serum and 3 years from the onset, the patient was diagnosed as multiple myeloma by bone marrow examination. It is speculated that abnormal immunological reactions related to multiple myeloma caused scleroderma-like lesions.