Journal of Materials Chemistry B · 2015 · 24 citations · 31 references
Natural SciencesMaterials SciencePharmacologyDrug DeliveryNanomaterialsPolymer ChemistryNanomedicineNanoparticle CharacterizationNanoparticle FormulationsOptical PolymersPolymeric NanomaterialsPolymeric NanoparticlesAdenosine Diphosphate-induced Platelet AggregationFluorescent ProbesNanoparticle-based ProbesPlatelet Aggregation InhibitionPolymer NanoparticlesPolymeric Nanoparticle FormulationPolymeric Nanoparticle StabilityStealth Nanoparticles
, stealth CPNs caused ∼10% erythrocyte haemolysis, which was likely due to unbound pegylated surfactant present in the formulation. Incubation of CPNs with both whole blood and isolated platelets showed no platelet activation, increases in platelet-monocyte aggregates or induction of platelet aggregation. Interestingly, PPE-CPN formulations inhibited adenosine diphosphate (ADP)-induced platelet aggregation in a dose-dependent manner, while PPV-CPNs did not show this effect. In conclusion, stealth CPN formulations exhibiting neutrally charged, pegylated surfaces do not stimulate platelet activation or aggregation, but may induce a low degree of haemolysis in the presence of free surfactant and can inhibit physiological mediators of platelet aggregation, such as ADP.
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Nanoparticle‐induced platelet aggregation and vascular thrombosis
Anna Radomski, Paul Jurasz, David Alonso‐Escolano et al. · British Journal of Pharmacology · 2005 · 629 citations · Full text