Concepedia

Physostigmine Reverses Propofol-induced Unconsciousness and Attenuation of the Auditory Steady State Response and Bispectral Index in Human Volunteers

Pascal Meuret, Steven B. Backman, Vincent Bonhomme, Gilles Plourde, Pierre Fiset

Anesthesiology · 2000 · 174 citations · 37 references

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Abstract

These findings suggest that the unconsciousness produced by propofol is mediated at least in part via interruption of central cholinergic muscarinic transmission.

References

37

The Influence of Age on Propofol Pharmacodynamics

Thomas W. Schnider, Charles F. Minto, Steven L. Shafer et al. · Anesthesiology · 1999 · 1.1K citations

Cellular bases of neocortical activation: modulation of neural oscillations by the nucleus basalis and endogenous acetylcholine

Raju Metherate, JH Ashe · Journal of Neuroscience · 1992 · 590 citations · Full text

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Brain Mechanisms of Propofol-Induced Loss of Consciousness in Humans: a Positron Emission Tomographic Study

Pierre Fiset, Tomáš Paus, Thierry Daloze et al. · Journal of Neuroscience · 1999 · 475 citations · Full text

, , +23

Fast oscillations (20-40 Hz) in thalamocortical systems and their potentiation by mesopontine cholinergic nuclei in the cat.

Mircea Steriade, Roberto Curro ́Dossi, Denis Paré et al. · Proceedings of the National Academy of Sciences · 1991 · 450 citations · Full text

, , +20

Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection

Greg Plummer · Journal of Chromatography B Biomedical Sciences and Applications · 1987 · 307 citations

, , +10