Stage‐specific skeletal and visceral defects of the I_Kr‐blocker almokalant: Further evidence for teratogenicity via a hypoxia‐related mechanism

Abstract

The stage specificity of observed visceral and skeletal defects correlates well with what has been reported in the literature after temporary interruption of oxygen supply during the same stages of development. The protective effect by PBN present further evidence that the teratogenicity of potent I(Kr)-blockers is related to induction of hypoxia- reoxygenation injury due to embryonic cardiac arrhythmia.