Applied Organometallic Chemistry · 2008 · 22 citations · 28 references
Natural SciencesChemical EngineeringChemistryCatalysisIndustrial ChemistryReaction EngineeringCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic MaterialsCatalytic Reaction EngineeringCross-coupling ReactionsBimetallic Catalyst DesignBimetallic CatalystsCatalyst Structure - Activity RelationshipsIndole ChemistryIndole DerivativesIndole SynthesisMild Reaction ConditionsPalladium Catalysts
Abstract Iron–palladium is a superior bimetallic catalyst in the presence of acetylacetone (Acac) with remarkable synergistic effect for the Michael‐type Friedel–Crafts reactions of indoles with chalcones. This catalytic system has the advantages of mild reaction conditions, smaller amount of metal salts, high yields of the desired products and operational simplicity, which make it a useful and promising process for the synthesis of indole derivatives. Copyright © 2009 John Wiley & Sons, Ltd.
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