Concepedia

The preparation of <sup>11</sup>C‐labeled caffeine

H. Denutte, T. Vandewalle, H. Cattoir, C. Vandecasteele, J. A. Jonckheere, Guido Slegers, C.F. Gelijkens, A.P. De Leenheer

Journal of Labelled Compounds and Radiopharmaceuticals · 1982 · 13 citations · 5 references

DOI

Concepts

Abstract

Abstract A rapid and mild procedure for the preparation of [ N ‐7‐ methyl ‐ 11 C] caffeine is described. Gaseous 11 C‐methyl iodide wa led into dimethyl sulphoxide (DMSO), containing theophylline (1,3‐dimethylaxanthine) and sodium hydride. Purification of the reaction product was achieved by High Performance Liquid Chromatogrphy (HPLC).

References

5

Isolation and Identification of Drugs

Keith Simpson · Journal of Clinical Pathology · 1970 · 512 citations · Full text

, , +10

Synthesis of methyl iodide-11C and formaldehyde-11C

Christian Marazano, M. Mazière, G. Berger et al. · The International Journal of Applied Radiation and Isotopes · 1977 · 127 citations

, , +7

The simultaneous determination of theophylline, theobromine and caffeine in plasma by high performance liquid chromatography

T. Foenander, Donald Birkett, John O. Miners et al. · Clinical Biochemistry · 1980 · 37 citations

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Study of the demethylation of [1,3,7-Me-13C] caffeine in man using respiratory exchange measurements

Maurice J. Arnaud, A. Thelin-Doerner, Éric Ravussin et al. · Journal of Mass Spectrometry · 1980 · 32 citations

, , +11

Gas-liquid chromatography of pyrimidine and purine nucleosides as their N,O-permethyl derivatives

A.P. De Leenheer, C.F. Gelijkens · Analytical Chemistry · 1976 · 28 citations

, , +9