GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.7K citations

Life Sciences, Biochemistry, Biomolecular Modeling +16

Why Nature Chose Phosphates

F. H. Westheimer · Science · 1987 · 1.7K citations

Life Sciences, Biochemistry, Molecular Biology +8

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

Claudia A. Landis, Susan B. Masters, Anna Spada et al. · Nature · 1989 · 1.4K citations

Life Sciences, Endocrinology, Molecular Biology +16

Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

E.F. Pai, Ute Krengel, Gregory A. Petsko et al. · The EMBO Journal · 1990 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

David E. Coleman, Albert M. Berghuis, E Lee et al. · Science · 1994 · 832 citations

Life Sciences, Biochemistry, Molecular Biology +17