Cytochrome P450 2C9 is Involved in Flow-Dependent Vasodilation of Peripheral Conduit Arteries in Healthy Subjects and in Patients with Chronic Heart Failure

Abstract

FMD in human conductance arteries is reduced after inhibition of CYP 2C9, supporting the concept that CYP 2C metabolites contribute to endothelium-mediated vasodilation of peripheral conduit arteries in vivo. In patients with heart failure, the CYP-dependent FMD appears to be preserved.