An Analytical Method for Size and Shape Characterization of Blood Lipoproteins

Abstract

In summary, the design software we describe is useful for estimating device performance and creating microfluidic chip layouts; these layouts can be rapidly modified to design chips that meet performance requirements. We used the software to improve the design of a microfluidic immunoassay chip. The resulting design occupied 25% of the area of the original chip, and the time required for electrophoretic separation was decreased by more than 50% relative to the original design, allowing for a faster assay. This process is more than 2 orders of magnitude faster than conventional design techniques and is ideally suited for design optimization of microfluidic lab-on-a-chip systems.