Concepedia

Chemo-Enzymatic Synthesis of Fmoc-Peptide Fragments

Shui‐Tein Chen, Shu‐Chyong Hsiao, Chung‐Ho Chang, Kung‐Tsung Wang

Synthetic Communications · 1992 · 15 citations · 11 references

DOI

Concepts

Abstract

Abstract Optically pure Fmoc-peptide fragments have been prepared via dicyclohexylcarbodiimide coupling of N-protected amino acids with amino acid esters, followed by enzyme-catalyzed ester hydrolysis by alcalase with a high concentration of organic solvent in a high yield.

References

11

9-Fluorenylmethoxycarbonyl amino-protecting group

Louis A. Carpino, Grace Han · The Journal of Organic Chemistry · 1972 · 1K citations

, , +9

Peptide synthesis. Part 2. Procedures for solid-phase synthesis using N<sup>α</sup>-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptide

Eric Atherton, C. J. Logan, R. C. Sheppard · Journal of the Chemical Society Perkin Transactions 1 · 1981 · 401 citations

, , +14

PREPARATION AND PROPERTIES OF <i>N</i>α‐9‐FLUORENYLMETHYLOXYCARBONYLAMINO ACIDS BEARING <i>TERT.</i>‐BUTYL SIDE CHAIN PROTECTION

Chi‐Deu Chang, Michinori Waki, Mushtaq Ahmad et al. · International journal of peptide & protein research · 1980 · 196 citations

, , +16

Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxyamino acids using succinimidyl carbonates

Alenka Paquet · Canadian Journal of Chemistry · 1982 · 181 citations · Full text

, , +9

Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations

Chi Huey Wong, S.-T. Chen, William J. Hennen et al. · Journal of the American Chemical Society · 1990 · 178 citations

, , +9