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Synthesis and Lipase-Catalyzed Enantiotope Selective Acetylation of 2-Benzoyloxy-1,3-propanediol
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1999
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Vinyl AcetateBiochemistryPorcine Pancreatic LipaseOrganic ChemistryEnantiotope Selective AcetylationStereoselective SynthesisPharmacologyAsymmetric CatalysisEnantioselective SynthesisLipid Synthesis
Preparation and porcine pancreatic lipase (PPL)-catalyzed enantiotope selective acetylation of the prochiral 2-benzoyloxy-1,3-propanediol (1a) is described. The reaction with PPL and vinyl acetate gave monoacetate (2a) of 96% e.e.