Smokeless tobacco increases aneuploidy in oral <scp>HPV</scp>16 E6/E7‐transformed keratinocytes <i>in vitro</i>

Abstract

The effect of STE varied in the cell lines studied. STE2 increased significantly the proportion of aneuploid cells in HPV-positive oral keratinocytes, but not HPV16 E6/E7 expression. This indicates that tobacco products may enhance the effects of HPV 16 and the risk of DNA aneuploidy increasing risk to malignant transformation.