Ni(<scp>ii</scp>)–salt catalyzed activation of primary amine-sp³C_α–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles

Abstract

NiCl2·6H2O and Ni(OAc)2·4H2O were found as efficient catalysts for C-H activation of benzyl and aliphatic amines for an unprecedented multi C-N bond forming cyclization with 1,2-diketones under refluxing toluene to furnish highly substituted and polycyclic imidazoles.