Tin(IV) complexes of 2‐benzoylpyridine <i>N</i>(4)‐phenyl‐thiosemicarbazone: spectral characterization, structural studies and antifungal activity

Abstract

Abstract Three tin(IV) complexes of 2‐benzoylpyridine N (4)‐phenylthiosemicarbazone (H2Bz4Ph) were prepared: [Sn(L)Cl 3 ] (1), [BuSn(L)Cl 2 ] (2) and [(Bu) 2 Sn(L)Cl] (3), in which L stands for the anionic ligand formed upon complexation with deprotonation and release of HCl. The complexes were characterized by a number of spectroscopic techniques. The crystal structures of H2Bz4Ph and complex 3 were determined. The antifungal activity of the ligand and its tin(IV) complexes was tested against Candida albicans . The thiosemicarbazone proved to be more active than the tin(IV) complexes. Copyright © 2003 John Wiley &amp; Sons, Ltd.