Overexpression of Cyclooxygenase-2 Is Associated with a Favorable Prognostic Phenotype in Breast Carcinoma

Abstract

The current data suggest that increased expression of COX-2 may be related to breast carcinomas with less aggressive phenotype. This suggestion is further supported by the positive correlation between COX-2 and PPARgamma, since the latter is considered to be indicative of a less malignant phenotype of tumor cells.