Application of High Pressure Induced by Water-Freezing to the Direct Catalytic Asymmetric Three-Component List−Barbas−Mannich Reaction

Abstract

High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List-Barbas-Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.