Protein Kinase C Inhibition Ameliorates Posttransplantation Preservation Injury in Rat Renal Transplants

Abstract

The PKC inhibitor sotrastaurin effectively ameliorated ischemia-reperfusion organ damage and promoted cytoprotection in a clinically relevant model of extended renal cold preservation followed by transplantation. Pharmacologic targeting of PKC may be beneficial for recipients receiving renal transplants at risk for delayed graft function.