Highly Enantioselective Addition of 1,3‐Diynes to Aldehydes Catalyzed by a Zinc–Amino Alcohol Complex

Abstract

Asymmetric catalysis: A highly enantioselective and efficient procedure for the amino alcohol-zinc-catalyzed addition of 1,3-diynes to various aromatic, α,β-unsaturated, and aliphatic aldehydes has been developed. The present catalytic system was successfully applied in the concise synthesis of natural products such as (S)-strongylodiols A and B (see scheme).