Synthesis, structural characterization, and ability to inhibit the growth of pancreatic cancer by organotin polymers containing chelidonic acid

Abstract

In this study, organotin polyesters have been formed from the interfacial reaction between the disodium salt of chelidonic acid and a variety of organotin dihalides. Reactions occur rapidly within less than 15 seconds. Yields vary from moderate to high, and chain length varies from 30 to 800 repeat units. Infrared spectral analysis shows the presence of the Sn–O linkage and is consistent with the geometry about the tin being generally a mixture of tetrahedral or nonbridging and octahedral or bridging. The organotin polyesters exhibit reasonable inhibition of two pancreatic cancer cell lines.