Nonsteroidal Anti-inflammatory Drugs and Upper Gastrointestinal Bleeding, Identifying High-Risk Groups by Excess Risk Estimates

Abstract

A history of peptic ulcer is associated with adverse outcome of NSAID therapy and should be regarded as a relative contraindication. A similarly strong effect of high age was shown. Male sex and short-term use are minor risk factors. The incidence of NSAID-related UGB can probably be reduced without affecting the overall utilization of NSAIDs.