An Efficient Method for the Production of Terminal Alkynes from 1,1‐Dibromo‐1‐alkenes and its Application in the Total Synthesis of Natural Product Dihydroxerulin

Abstract

Abstract An efficient method of preparing various terminal alkynes from 1,1‐dibromo‐1‐alkenes by using TBAF (tetra‐ n ‐butylammonium fluoride) as a base and triphenylphosphane as a reductant was developed. This method is strong base and low/high temperatures free, and can tolerate a broad range of substrates. These advantages were well demonstrated by the application of this method to the total synthesis of polyene natural product dihydroxerulin. magnified image