Concepedia

Palladium Nanoparticle‐Catalyzed Direct Ethynylation of Aliphatic Carboxylic Acid Derivatives <i>via</i> C(<i>sp</i><sup>3</sup>)H Bond Functionalization

Mohammad Al‐Amin, Mitsuhiro Arisawa, Satoshi Shuto, Yusuke Ano, Mamoru Tobisu, Naoto Chatani

Advanced Synthesis & Catalysis · 2014 · 58 citations · 34 references

DOI

Abstract

Abstract We have developed a sulfur‐modified, gold‐supported palladium material (SAuPd) with palladium, Pd, nanoparticles on its surface; it is a recyclable, low‐leaching Pd catalyst. Here we report, using SAuPd, the first example of Pd nanoparticle‐catalyzed, unactivated C( sp 3 )H bond functionalization of amides, using 8‐aminoquinoline as a directing group, to yield ethynylated products. The low leaching properties of SAuPd enabled it to be recycled and reused 10 times for C( sp 3 )H bond functionalization. magnified image

References

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