<i>N</i>‐acylation of <i>N</i>‐methylcarbamate insecticides and its effect on biological activity

Abstract

Abstract N ‐Acylated N ‐methylcarbamates have been prepared and tested for contact/stomach poison and systemic insecticidal activities, mammalian toxicity and in vitro anticholinesterase activity. The N ‐acyl derivatives in general have lower mammalian toxicities and somewhat lower insecticidal activities than the corresponding unacylated N ‐methylcarbamates and are relatively poor inhibitors of bee cholinesterase. Tentative reasons are given for these effects.