Gut · 1988 · 68 citations · 18 references
MedicineClinical SciencesInternal MedicineGastroenterologyImmunopathologyMucosal ImmunologyBowel Function AssessmentColonic DiseasesGastrointestinal InflammationGastrointestinal PathologyInflammatory Bowel DiseaseMucosal PermeabilityClinical RemissionColonic InflammationColonic PathologyGastrointestinal Function AssessmentInflammatory Bowel Disease Activity AssessmentInflammatory Bowel Disease PathophysiologyIntestinal Barrier PermeabilityMannitol Challenge Test
The mannitol-lactulose intestinal permeability test was evaluated in 100 healthy controls and 47 patients with Crohn's disease. These patients were further separated into three subgroups of increased activity (Harvey-Bradshaw index) and in two subgroups, with elective colonic lesions and associated ileal and colonic lesions. Results were given as percentages of urinary recoveries for mannitol (M), lactulose (L), and L/M ratio. As a whole, patients with Crohn's disease have lower mean M and higher mean L and mean L/M ratios than controls. The magnitude of alterations in M, L, and L/M increased with activity. The sensitivity of the test, however, reached interesting figures (67%:L and 86%:L/M) only in subgroup III which was composed of relapsing patients. Mean M was lower in patients with associated ileal lesion but, whatever the criterion (M, L, or L/M), the test does not provide any clue for the detection of a possible infraclinical associated ileal localisation.
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A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY
Richard F. Harvey, J.M. Bradshaw · The Lancet · 1980 · 3K citations
Intestinal permeability in children with Crohn's disease and coeliac disease.
A D Pearson, E J Eastham, M F Laker et al. · BMJ · 1982 · 233 citations · Full text