Direct Aminolysis of Unactivated Esters at High‐Pressure

Abstract

The preparation of amides 3 from nonactivated esters 1 and secondary amines 2 has been achieved at 8 kbar and approximately 45°C. This reaction cannot be carried out at normal pressure without a catalyst; even the reaction with primary amines (uncatalyzed, normal pressure) requires temperatures above 200°C. equation image