Renal Disease and the Metabolic Effects of Tetracycline

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Article1 March 1963Renal Disease and the Metabolic Effects of TetracyclineMAURICE E. SHILS, M.D., SC.D.MAURICE E. SHILS, M.D., SC.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-3-389 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReports of an azotemic effect of tetracyclines in certain patients have appeared sporadically since the initial observation of Batemanet al. on patients infused with oxytetracycline (1, 2) or chlortetracycline (2). The occasional clinical reports have been supported by studies with experimental animals, and indicate some association of unknown mechanism between tetracycline and an elevation in blood urea or non-protein nitrogen. Metabolic studies performed by Gabuzdaet al. (3) and Faloonet al. (4-6) in patients reportedly without significant renal disease indicated that members of this group of antibiotics were capable of increasing urinary nitrogen excretion. This literature has been...References1. BATEMANBARBERIOBRICEKLOPPPIERPONT JCJRPCTH: Fatal complications of intensive antibiotic therapy in patients with neoplastic disease. Arch. Intern. Med. 90: 763, 1952. CrossrefGoogle Scholar2. BATEMANKLOPPSAMSON JCCTR: Effect of nephrectomy on azotemia associated with parenteral antibiotic administration. Antibiot. Ann. 1953-54: 531, 1954. Google Scholar3. GABUZDAGOCKEJACKSONGRIGSBYLOVEFINLAND GJTMGGMEBDM: Some effects of antibiotics on nutrition in man, including studies of the bacterial flora of the feces. Arch. Intern. Med. 101: 476, 1958. CrossrefGoogle Scholar4. FALOONNOLLPRIOR WWJWJT: Nitrogen metabolism and liver histology during Aureomycin administration in patients with hepatic disease. J. Lab. Clin. Med. 41: 596, 1953. MedlineGoogle Scholar5. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Division of Experimental Surgery and Physiology of the Sloan-Kettering Institute for Cancer Research, The Department of Medicine, Memorial Hospital for Cancer and Allied Diseases and James Ewing Hospital, and the Cornell University Medical College, New York, New York.Supported in part by a grant (C-3817) from the National Cancer Institute, National Institutes of Health, United States Public Health Service.Presented in part at the Forty-third Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.Requests for reprints should be addressed to Maurice E. Shils, M.D., Box 181, Sloan-Kettering Institute, 410 East 68th Street, New York 21, New York. 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