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Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogs
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1984
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2-Amino-3-benzoylphenylacetic AcidBioorganic ChemistryAntiinflammatory AgentsPharmacotherapyChemical DerivativePharmaceutical ChemistryMedicinal ChemistrySeveral DerivativesSubstituted DerivativesDerivativesBiochemistryFluorous SynthesisPharmacological AgentPharmacologyAnti-inflammatoryNatural SciencesPharmacological EvaluationMedicineDerivative (Chemistry)Drug Discovery
A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4'-chloro), 158 (4'-bromo), and 182 (5-chloro, 4'-bromo) were more potent than indomethacin in these assays.