Association of polymorphisms in the human surfactant protein‐D (SFTPD) gene and postnatal pulmonary adaptation in the preterm infant

Abstract

The finding of an association of a variant of the SFTPD gene, that has previously been shown to be associated with increased SP-D serum levels in adult patients with acute respiratory failure, i.e. RDS in preterm infants, may provide a basis for the initial risk assessment of RDS and modification of surfactant treatment strategies. A role for SP-D in neonatal pulmonary adaptation has to be postulated.