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Total synthesis of scutellarin-7-<i>O</i>-Glucuronide
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2005
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Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesTotal SynthesisL. FarkasHydroxyl ProtectionMichael AdditionPharmacologyPharmaceutical ChemistrySynthetic ChemistryNatural Product Synthesis
Scutellarin-7-O-glucuronide (1) has been synthesized from 2-hydroxyl-4,5,6-trimethoxyacetophenone through eight steps, including Michael addition, cyclization, hydrogenation, hydroxyl protection, deprotection, etc. The overall yield of 13% is much higher than that reported (0.6%) by L. Farkas, G. Mezey-Vàndor et al. in 1974.