Evaluation of the GenoType® MTBDR<i>plus</i> assay and identification of a rare mutation for improving MDR-TB detection

Abstract

Although Genotype MTBDRplus is a rapid and reliable molecular test for detecting MDR-TB, a significant proportion of strains in China contain a rare katG S315N mutation that would be missed by the assay. Further improvements may be achieved by incorporating this mutation into the assay to increase sensitivity in detecting INH resistance in China.