Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry

Abstract

“Clicked” into place: Densely grafted poly(γ-propargyl-L-glutamate)-g-poly(ethylene glycol) polypeptides have been synthesized by combining ring-opening polymerization of N-carboxyanhydrides with click chemistry. Various lengths of poly(ethylene glycol) (PEG) side chains (750 g mol−1 to 5000 g mol−1) were attached to a rigid α-helical poly(γ-propargyl-L-glutamate); extremely high grafting efficiencies of over 96 % were achieved. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.