Reflexive attentional orienting in migraineurs: The behavioral implications of hyperexcitable visual cortex

Abstract

INTRODUCTION: Although migraine is classified as a headache disorder, a key part of migraine pathophysiology is a heightened excitability of visual cortices in between headache events. The goal of our study was to examine the behavioral impact of this visuocortical hyperexcitability, in terms of its effect on reflexive visual attentional orienting. METHODS AND RESULTS: In Experiment 1, using a non-predictive spatial cuing task that relied on sensory-evoked responses in the visual cortex for triggering attentional orienting, we found that migraineurs had greater attentional enhancement of manual target responses, relative to non-migraine controls. In two control experiments we confirmed that this heightened attention effect in migraineurs is not due to exaggerated reflexive orienting responses in general, but rather, it appears to be specifically associated with sensory-evoked attentional triggers. DISCUSSION: Taken together, this confirms that the functional consequences of hyperexcitable visual cortex in migraineurs are not just purely sensory in nature, but directly impact at least some forms of reflexive attention. This provides evidence of at least one cognitive implication of hyperexcitable visual cortical responses in migraineurs, namely heightened reflexive visual-spatial orienting specific to sudden-onset peripheral events.