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Cultivation of Tripterygium wilfordii Tissue Cultures for the Production of the Cytotoxic Diterpene Tripdiolide
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1983
Year
Incubation PeriodEngineeringBotanyTissue CulturesPlant PathologyDrug ResistancePhysiological Plant PathologyBiosynthesisPhytoalexinCell BiologyPhytotoxicityPhytochemistryCytotoxic Diterpene TripdiolideTripterygium WilfordiiBiologyBiotechnologyPlant Cell CultureT. WilfordiiMicrobiologyPlant ToxinMedicine
The production of the cytotoxic agent tripdiolide employing plant tissue cultures of TRIPTERYGIUM WILFORDII is demonstrated. Detailed investigations of a developed cell line of T. WILFORDII in terms of tripdiolide production versus variations in growth conditions, for example media composition, are presented. Also the age and size of the inoculum and the incubation period with respect to tripdiolide formation are evaluated.