Basic calcium phosphate crystal–induced prostaglandin E₂ production in human fibroblasts: Role of cyclooxygenase 1, cyclooxygenase 2, and interleukin‐1β

Abstract

These findings indicate that BCP crystals may be an important amplifier of PGE(2) production through induction of the COX enzymes and the proinflammatory cytokine IL-1beta.