Mechanisms of action of paracetamol and related analgesics

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

Naduviladath Vishvanath Chandrasekharan, Hu Dai, Katarina Roos et al. · Proceedings of the National Academy of Sciences · 2002 · 2K citations · Full text

Medicine, Biochemistry, Pharmacology +13

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Jane A. Mitchell, Pravit Akarasereenont, Christoph Thiemermann et al. · Proceedings of the National Academy of Sciences · 1993 · 1.7K citations

Medicine, Pharmacology, Inflammation +9

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full <i>in vitro</i> analysis

Timothy D. Warner, Francesco Giuliano, Ivana Vojnovic et al. · Proceedings of the National Academy of Sciences · 1999 · 1.5K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +12

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Makoto Murakami, Hiroaki Naraba, Toshihiro Tanioka et al. · Journal of Biological Chemistry · 2000 · 968 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15