Copper-catalyzed tandem N-arylation/condensation: synthesis of quinazolin-4(3H)-ones from 2-halobenzonitriles and amides

Abstract

A novel, straightforward and practical copper-catalyzed domino protocol for synthesis of quinazolin-4(3<italic>H</italic>)-one derivatives from commercially available 2-halobenzonitriles and amides was successfully developed.