Amine-Induced Michael/Conia-Ene Cascade Reaction: Application to a Formal Synthesis of (±)-Clavukerin A

Abstract

An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic beta-ketoesters as the substrates in one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (+/-)-Clavukerin A.