Liver Resection for Multiple Colorectal Liver Metastases with Surgery Up‐front Approach: Bi‐institutional Analysis of 736 Consecutive Cases

Abstract

In patients with multiple liver metastases, the number of liver metastases has less impact on the prognosis than other prognostic factors. Complete resection with repeat metastasectomy offers a chance of cure even in patients with numerous colorectal liver metastases (i.e., those with eight or more nodules). A further prospective study is necessary to clarify the optimal setting of preoperative chemotherapy.