Ontogenic changes of the control by phosphodiesterase‐3 and ‐4 of 5‐HT responses in porcine heart and relevance to human atrial 5‐HT₄receptors

Abstract

PDE3-induced control of porcine 5-HT responses differed in atrium and ventricle and changed with age. PDE3 and PDE4 jointly prevented fade of inotropic and cAMP responses to 5-HT in porcine atrium. Unlike porcine atria, only PDE3 induced fade of 5-HT responses in human atria.