ADAM22, Expressed in Normal Brain but not in High-Grade Gliomas, Inhibits Cellular Proliferation via the Disintegrin Domain

Abstract

ADAM22, a brain-specific cell surface protein, mediates growth inhibition using an integrin dependent pathway. It is expressed in normal brain but not in high-grade gliomas. A related protein, ADAM11, has only a minor effect on cell growth, and its expression is unchanged in low- and high-grade gliomas.