Isoniazid-Induced Acute Pancreatitis

Abstract

I n recent years, a resurgence of Mycobacterium tubercu-losis has occurred in the United States (1), resulting in a marked increase in the use of antituberculous drugs. Iso-niazid is a first-line drug in the treatment of tuberculosis and is increasingly being used as a chemoprophylactic agent. Severe adverse reactions with isoniazid have been observed; these include hepatitis, peripheral neuropathy, skin rashes, neurologic disturbances, and hematologic al-terations (2, 3). We describe a patient with the first well-documented case of isoniazid-induced acute pancreatitis. Case Report A 31-year-old man from India presented to the emer-gency department with complaints of several days of weakness, fever, vomiting, and persistent pain in the epi-gastrium. Three weeks before this presentation, he was