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THE ORIGIN OF IMMUNOGLOBULINS IN INTESTINAL SECRETION OF SHEEP
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1974
Year
Animal PhysiologyCaprineLaboratory ImmunologyAnimal ScienceImmunodeficienciesPathogenesisImmunologyVeterinary SciencePathologyGastroenterologyEducationImmunochemistryImmunoglobulin EDigestive TractMedicineVarious ImmunoglobulinsMajor ImmunoglobulinSerum Radioactivity Ratios
Summary Studies were made on the origin and mechanism of transfer of IgG 1 , IgG 2 , IgA and IgM into the secretion of isolated loops of jejunum of unanaesthetized sheep. IgA was the major immunoglobulin in intestinal secretion, although considerable quantities of IgG 1 and IgG 2 were also present. Secretion: serum radioactivity ratios for IgG 1 and IgG 2 were similar, indicating that they were transferred into intestinal secretion with equal facility. Specific radioactivities of the various immunoglobulins in serum and secretion were compared and the results suggested that all the IgG 2 and most of the IgG 1 were derived from blood plasma, whereas only a trivial amount of the IgA was plasma‐derived. The slow equilibration of IgM, together with its relatively short biological ‘half‐life', prevented accurate assessment of plasma contribution of this immunoglobulin.