MedChemComm · 2012 · 143 citations · 78 references
PharmacyMedicinal ChemistryMolecular BiologyDrug DiscoveryProtein BiochemistryDrug-receptor InteractionsMolecular Targets Of DrugsProtein BindingDrug-protein Interaction NetworksPolypharmacyProtein Sequence EvolutionProtein-drug BindingProtein-protein Interaction EvolutionRational Polypharmacology
The ability of many drugs, unintended most often, to interact with multiple proteins is commonly referred to as polypharmacology. Could this be a reminiscent chemical signature of early protein evolution?
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