Open randomized study of pyrimethamine–sulphadoxine <i>vs.</i> pyrimethamine–sulphadoxine plus probenecid for the treatment of uncomplicated <i>Plasmodium falciparum</i> malaria in children

Abstract

The combination of pyrimethamine-sulphadoxine, and probenecid, at a relatively moderate dose, improved treatment efficacy but had no effect on gametocyte carriage. The pyrimethamine-sulphadoxine-probenecid combination merits further evaluation as a potential treatment for use in Nigeria.