THE TREATMENT OF ANURIA DUE TO SULFAPYRIDINE CALCULI

Abstract

The symptom complex of hematuria, abdominal pain, and nitrogen retention as a manifestation of sulfapyridine therapy was first described by Southworth and Cooke, 1 although the occurrence of hematuria had been previously noted. 2 Animal experiments by Antopol and Robinson, 3 Gross, Cooper and Lewis 4 and Toomey 5 early revealed the pathologic changes in the urinary tract of rats, rabbits and monkeys receiving sulfapyridine. Since then, Antopol and Robinson 6 and Toomey, Reichle and Takacs 7 have studied these changes in great detail. Briefly they are as follows: in the kidneys, striking dilatation of the glomerular spaces and tubules; thickening of the basement membranes of the glomerular tufts with changes in the shape of the cells of the capsular epithelium; in the collecting tubules, debris and spaces, apparently the lodging place of crystals of the precipitated drug; in the pelves and ureters, concretions, with denuding of the epithelium, clotted