Bulletin of the Chemical Society of Japan · 2006 · 81 citations · 36 references
Natural SciencesChemistryMedicinal ChemistryAnalytical ChemistryOrganic ChemistryStructure-activity RelationshipsChemical Space AnalysisStructure-activity Relationship AnalysisAbsolute Configuration AssignmentAbsolute Configuration DeterminationChirality DeterminationRelative Configuration Determination
Abstract This article describes the application of the modified Mosher’s method to a variety of natural products possessing a secondary alcohol for determining their absolute configuration. The method is generally applicable to secondary alcohols with a few exceptions where the hydroxy group is seriously hindered by neighboring substituents. Countermeasures to solve the problems are also described. Recent findings that the modified Mosher’s method can be used in solvents other than deutero-chloroform are included. Development and application of the sulfoximine method for the determination of the absolute configuration of chiral sulfoxides are also described.
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