Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

Kazuhiro Ito, Sam Lim, Gaetano Caramori et al. · Proceedings of the National Academy of Sciences · 2002 · 513 citations

Medicine, Molecular Biology, Pharmacology +16

Anti-inflammatory effects of low-dose oral theophylline in atopic asthma

Patrick S. Sullivan, ZH Jaffar, Clive Page et al. · The Lancet · 1994 · 406 citations

Medicine, Immunology, Pharmacology +13

Evaluation of sodium alginate as drug release modifier in matrix tablets

Celine Valeria Liew, Lai Wah Chan, Ai Ling Ching et al. · International Journal of Pharmaceutics · 2005 · 244 citations

Pharmacy, Pharmaceutics, Controlled Release Formulations +15

Thermally reversible xyloglucan gels as vehicles for rectal drug delivery

Shôzô Miyazaki, Fumie Suisha, Naoko Kawasaki et al. · Journal of Controlled Release · 1998 · 218 citations

Pharmacy, Bioengineering, Pharmaceutics +14

Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum

Jei‐Man Ryu, Suk-Jae Chung, Min-Hwa Lee et al. · Journal of Controlled Release · 1999 · 130 citations

Pharmacy, Pharmacokinetics, Pharmacology +12